
What forms the core of the supplementation protocols of the world's longevity icons, now in a single product. BrainMax NAD+ Eternal combines five substances that have long been used by celebrities such as David Sinclair, Andrew Huberman and Peter Attia. High dose nicotinamide riboside with polyphenols, which are the most discussed substances in longevity research. A targeted supplement for those who want to follow the path of top experts.


Longevity is a global trend led by science. Substances such as nicotinamide riboside, fisetin, resveratrol or apigenin appear in the personal protocols of the most respected longevity experts. David Sinclair (Harvard, author of The End of Aging) has long been using resvetatrol, fisetin and NAD+ precursors. Bryan Johnson combines NR and fisetin in his daily routine of his Blueprint protocol, also documented on Netflix's platform called Don't Die: A man who wants to live forever. Dr. Andrew Huberman recommends apigenin, NR and quercetin in his podcast, which has millions of listeners per month.

Nicotinamide riboside chloride is a state-of-the-art NAD+ supported precursor that does not require a complex transport mechanism. It is repeatedly mentioned by scientists such as David Sinclair, Andrew Huberman and Peter Attia, the latter two discussing this molecule in relation to circadian rhythms and mitochondrial function. NR is one of the most effective ways to replenish NAD+ in the body.

NR plays a key role in energy metabolism¹. NR in combination with polyphenols such as resveratrol and quercetin form the comprehensive basis of modern supplementation protocols. A dose of 300 mg is equivalent to approximately 100 mg of niacin. Compared to niacin, however, it does not cause skin redness and is thus suitable for long-term use. Niacin contributes to:

Polyphenols are a group of plant molecules that are among the most debated in longevity research. These natural substances are being investigated for their unique biochemical properties such as interacting with cellular enzymes, influencing cellular signaling pathways and participating in processes that are the focus of modern longevity science. In combination with nicotinamide riboside, it forms a unique and sophisticated synergy. Where are they found?
It is one of the most studied polyphenols. Resveratrol is the active ingredient extracted from Japanese wingwort, a plant that is a known antioxidant. It is the iconic molecule of the longevity movement. It was first popularized by David Sinclair as sirtuin activator (SIRT1). Quercetin is often mentioned in connection with senolytics. Bryan Johnson includes it in his longevity protocol.
Apigenin is a flavonoid naturally found in chamomile, celery or parsley. Andrew Huberman mentions it often on his podcast, especially in relation to its role in supplementation protocols. Fisetin, on the other hand, is a polyphenol found in strawberries, apples or grapes and is one of the molecules that has received increasing attention in recent years. Both substances have thus become part of modern supplement stacks, including those built by Bryan Johnson.



| Nutritional component | Quantity in 1 dose |
|---|---|
| Nicotinamide riboside chloride 99 % | 300 mg |
| Quercetin | 250 mg |
| Resveratrol | 6 mg |
| Apigenin 98 % | 500 mg |
| Fisetin | 5 mg |
2 capsules per day.
Package size:
60 herbal capsules.
At room temperature, in a dry and dark place.
Dietary supplement. Not for use by children, pregnant or nursing women unless recommended by a physician. There is no substitute for a varied diet. Keep out of reach of children. Do not exceed the recommended daily dose. Maintain a healthy lifestyle.
Martens, C. R., Denman, B. A., Mazzo, M. R., Armstrong, M. L., Reisdorph, N., McQueen, M. B., Chonchol, M., & Seals, D. R. (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature communications, 9(1), 1286.
Airhart, S. E., Shireman, L. M., Risler, L. J., Anderson, G. D., Nagana Gowda, G. A., Rafters, D., Tian, R., Shen, D. D., & O'Brien, K. D. (2017). An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PloS one, 12(12), e0186459.
Zhou, D. D., Luo, M., Huang, S. Y., Saimaiti, A., Shang, Gan, R. Y., & Li, H. B. (2021). Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases. Oxidative medicine and cellular longevity, 2021, 9932218. Mantadaki, A. E., Baliou, S., Linardakis, M., Wakonaki, Tzatzarakis, M. N., Tsatsakis, A., & Symvoulakis, E. K. (2024). Quercetin Intake and Absolute Telomere Length in Patients with Type 2 Diabetes Mellitus: Novel Findings from a Randomized Controlled Before-and-After Study. Pharmaceuticals, 17(9), 1136.
Ciccone, L., Pyragine, E., Brogi, S., Camodeca, C., Fucci, R., Calderone, V., Nencetti, Martelli, A., & Orlandini, E. (2022). Resveratrol-like Compounds as SIRT1 Activators. International journal of molecular sciences, 23(23), 15105. Cao, W., Dou, Y., & Li, A. (2018). Resveratrol Boosts Cognitive Function by Targeting SIRT1. Neurochemical research, 43(9), 1705-1713.
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